Summary

Top 16 papers analyzed

The immunoglobulin G antibodies initially produced after SARS-CoV-2 infection decay over time and may vanish after a few months. Whether this impacts immunity to reinfection is unclear but worrying about antibody waning. Studies evaluating serological responses after vaccination can provide insights into the dynamics of the immune response post-immunization. Here we measured IgG antibodies to the SARS-CoV-2 spike protein at 5-6 weeks and about 7 months after the 2nd dose of BNT162b2 or ChAdOx1 nCoV-19. Antibody levels remained stable or declined modestly in most participants but fell below the positivity cut-off in 15-20%. The steepest declines occurred in the elderly and after ChAdOx1 nCoV-19. Pre-existing SARS-CoV-2 immunity at vaccination modestly reduced IgG responses. SARS-CoV-2-specific CD4+T cell responses were maintained despite declining antibodies. Our findings suggest a risk of decreasing antibody-mediated immunity to SARS-CoV-2 within a year after vaccination, especially in the elderly and after adenoviral-vector vaccination, despite maintained T cell responses.

D-dimers levels can predict poor outcomes in children with SARS-CoV-2 infection or MIS-C. High D-dimer values are associated with an increased risk of pediatric intensive care unit admission.

Published By:

Child (basel - Children

2022

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9

The study compared the antibody levels in vaccinated individuals and identified factors that affect immune response to SARS-CoV-2 vaccines. Factors such as vaccine type, presence of symptoms, and time between doses influenced antibody titers. Spikevax and Comirnaty vaccines showed no significant differences, while Vaxzevria resulted in more stable antibody levels compared to mRNA-based vaccines.

Published By:

Vaccines

2022

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2

Pool testing is a strategy that reduces time and costs in detecting SARS-CoV-2. The study shows that pool testing can detect even a single positive sample in pools of 34 samples, and can be extended to use saliva for self-collection.

Published By:

Plo ONE - PLoS ONE

2022

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1

The study assessed the waning of SARS-CoV-2 antibodies after vaccination. Preliminary results indicate a decline in levels, which may have implications for further vaccinations in Germany.

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Eur J Public Health - European Journal of Public Health

2022

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0

Hypertension can develop in patients hospitalized with SARS-COV2, and it may persist in the post-covid syndrome. This condition requires personalized treatment due to its complex pathogenic mechanisms.

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J Hypertens - Journal of Hypertension

2022

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0

The study analyzed COVID-19 testing results for people experiencing homelessness in Denver. The findings showed that a higher percentage of individuals tested positive for the virus in shelters compared to encampments, highlighting the need for ongoing mitigation strategies in shelters.

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3

COVID-19 affects the liver, causing mild to moderate elevations in liver blood tests. The exact mechanisms of liver damage are still unknown.

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Frontline Gastroenterol - Frontline Gastroenterology

2020

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1

Current methods for diagnosing the SARS-CoV-2 virus, which causes COVID-19, often yield false-negative results. However, using routine blood tests along with artificial intelligence-based models, such as Random Forest and logistic regression, can provide accurate diagnoses.

Published By:

Diagnostics

2023

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0

The study analyzed the levels of AST and LDH in patients admitted to a hospital in Italy before and during the COVID-19 outbreak. There was no evidence of a significant number of COVID-19 cases before February 20th, 2020, suggesting that the virus was circulating in low amounts or through asymptomatic individuals. Routine blood tests could be used as a surveillance indicator for a possible second wave.

Published By:

Acta bio-medica Atenei Parm - Acta bio-medica : Atenei Parmensis

2020

Cited By:

2

Vaccination with the AstraZeneca and BioNTech/Pfizer COVID-19 vaccines can lead to the production of antibodies that activate platelets, but these antibodies are mostly low in levels and do not have significant clinical importance. Therefore, caution should be exercised when interpreting positive results for these antibodies in vaccinated individuals.

Published By:

Blood

2021

Cited By:

111

The study assessed the prevalence of COVID-19 antibodies among healthcare workers in Poland and identified risk factors. The prevalence among HCW was 25.2%, with the highest rates seen among those with home or work-related contact with COVID-19 cases.

Published By:

Med Pr - Medycyna Pracy

2022

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5

During the COVID-19 pandemic, different variants of the SARS-CoV-2 virus have emerged and spread globally. A study found significant differences in blood cell counts and biomarkers among patients infected with the Alpha, Delta, and Omicron variants. This suggests that both the virus variants and the laboratory parameters used to evaluate patients' status at admission are subject to changes during the pandemic.

Published By:

Biomedicines

2023

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3

A study investigated whether laboratory blood tests can distinguish between SARS-CoV-2 and influenza infections in emergency department patients. A random forest model incorporating 15 laboratory tests and demographic characteristics achieved an 83% agreement with RT-PCR results and identified serum calcium level as the most impactful feature for differentiation.

Published By:

medRxiv

2021

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0

Since the beginning of the COVID-19 pandemic, there has been interest in understanding its impact on chronic kidney disease (CKD) patients. A single-center pilot study evaluated CKD patients with COVID-19 and found that most had a favorable outcome, but female CKD patients with comorbidities had a higher risk of unfavorable prognosis. Further research is needed to understand the impact of COVID-19 on CKD patients.

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Nephrology Dialysis Transplantation - Nephrology, Dialysis and Transplantation

2021

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0

Vaccination against SARS-CoV-2 can significantly reduce symptoms of COVID-19 by increasing IgG levels, CD8+ T cells, and eosinophils, and regulating coagulation function. The vaccine remains protective against SARS-CoV-2.

Published By:

Front Immunol - Frontiers in Immunology

2022

Cited By:

2

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0