Summary
Melatonin has been shown to have significant effects on the gut microbiota, with implications for various health conditions. Studies indicate that higher serum melatonin levels are associated with a reduced risk of type 2 diabetes, with alterations in gut microbiota such as an increase in Bifidobacterium and a decrease in Coprococcus observed in individuals with diabetes. This suggests melatonin may play a therapeutic role in managing diabetes by influencing gut microbiota composition and tryptophan metabolism, potentially reducing inflammation and other diabetes-related traits. Additionally, melatonin has been shown to modulate the gut microbiota in conditions like obesity and inflammatory bowel disease, potentially serving as a probiotic agent to restore balance. Melatonin's roles extend beyond metabolic regulation, as it demonstrates potential in alleviating dysbiosis-related disorders, sleep deprivation, and oxidative stress. Its antioxidative and anti-inflammatory effects, coupled with its ability to regulate circadian rhythms and immune responses, support its use in diverse therapeutic contexts. Furthermore, melatonin's interaction with gut microbiota is linked to neurological conditions, highlighting its integration within the microbiome-gut-brain axis. These findings underscore the promising potential of melatonin as a multifaceted agent in health management, with more research needed to fully understand its mechanisms and applications.
Consensus Meter
Higher melatonin levels link to reduced type 2 diabetes risk. Gut microbiota plays a critical role.
Published By:
X Huang, Y Qiu, Y Gao, R Zhou, Q Hu, Z He, Y Lv… - Diabetologia, 2022 - Springer
Melatonin shows potential in treating intestinal diseases by modulating gut microbiota and immune cells. Its roles include synthesizing diverse metabolites, activating immune cells, and affecting microbial components.
Published By:
N Ma, J Zhang, RJ Reiter, X Ma - Medicinal Research Reviews, 2020 - Wiley Online Library
Melatonin may reduce breast cancer risk by modulating microbiota and estrogen metabolism. Dysbiosis and circadian disruption impact melatonin levels, influencing estrogen and breast cancer development.
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A Laborda-Illanes, L Sánchez-Alcoholado, S Boutriq… - Cancers, 2021 - mdpi.com
Gut microbiota aids melatonin production, benefiting intestinal health and brain-related diseases. Melatonin's effects may help prevent or treat conditions like Alzheimer's and Parkinson's.
Published By:
S Ahmadi, M Taghizadieh, E Mehdizadehfar… - Biomedicine & …, 2024 - Elsevier
Melatonin, produced in the gut, influences the microbiome, benefiting conditions like IBD and sleep disturbances. Its antioxidative, immunomodulatory, and circadian functions aid dysbiosis treatment.
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MI Iesanu, CDM Zahiu, IA Dogaru, DM Chitimus… - Antioxidants, 2022 - mdpi.com
Gut permeability and melatonin influence depression and related disorders. These factors affect immune responses and neuroregulatory processes.
Published By:
G Anderson, M Maes - Advances in Integrative Medicine, 2015 - Elsevier
Melatonin alleviates sleep deprivation-induced cognitive impairment by modulating gut microbiota. It downregulates Aeromonas and LPS while upregulating Lachnospiraceae and butyrate levels.
Published By:
X Wang, Z Wang, J Cao, Y Dong, Y Chen - Microbiome, 2023 - Springer
Melatonin reduces obesity and modulates gut microbiota in mice. It alters microbial composition, decreasing inflammation and improving insulin sensitivity.
Published By:
P Xu, J Wang, F Hong, S Wang, X Jin… - Journal of pineal …, 2017 - Wiley Online Library
Melatonin improves GI and metabolic functions in SCI mice by restoring gut microbiota balance. It enhances locomotor recovery and intestinal integrity while reducing inflammation.
Published By:
Y Jing, D Yang, F Bai, C Zhang, C Qin, D Li… - Journal of …, 2019 - liebertpub.com
Melatonin may modulate gut microbiota, improving dysbiosis-related disorders. It shows potential as a therapeutic agent for conditions like colitis, obesity, and sleep disruption.
Published By:
MI Iesanu, CDM Zahiu, IA Dogaru, DM Chitimus… - Antioxidants, 2022 - mdpi.com