Supplementation with an extract of Cucumis sativus L. (cucumber extract) at a dose of 20 mg/day has shown beneficial effects in patients with knee osteoarthritis (OA) over the age of 40. In an 8-week randomized double-blind placebo-controlled study, significant reductions in pain intensity were observed, with the experimental group experiencing more pronounced decreases compared to the placebo group. Additionally, improvements were noted in stiffness and physical function using the WOMAC index, as well as in the Timed Up and Go test. Muscle function improvements were evident, particularly in isometric and isokinetic exercises, alongside reductions in inflammatory biomarkers like interleukin-1-beta (IL-1β) and matrix metalloproteinase-3 (MMP-3). The study indicates that cucumber extract could be a valuable natural option for joint health maintenance in knee OA patients. Furthermore, Q-Actin, a standardized cucumber extract, demonstrated superior pain management properties compared to standard treatments in prior research. In a 180-day longitudinal placebo-controlled study, significant, dose-dependent improvements in pain-related parameters were reported, confirming Q-Actin's effectiveness versus placebo in managing moderate OA pain. These findings suggest that cucumber extract, whether as Q-Actin or in other formulations, holds promise for alleviating symptoms and inflammation associated with knee OA.