This meta-analysis aimed to evaluate the association between coffee consumption and chronic kidney disease (CKD). Four observational studies with 14 898 individuals were included. The pooled risk ratio (RR) of CKD in individuals consuming coffee was 0.71 (95% CI, 0.47-1.08). The subgroup analysis showed the pooled RRs of CKD of 1.10 (95% CI, 0.94-1.29) in males and 0.81 (95% CI, 0.58-1.13) in females, respectively. The conclusion from this study is that there is no significant association between coffee consumption and CKD in males, however further studies are necessary to assess the potential inverse association between coffee consumption and risk for developing CKD in females.

< 0.05. This study looked into the effects of decaffeinated coffee on kidney function and nucleotide metabolism in mice. After two weeks, activities of AMP deaminase, ecto5′-nucleotidase, adenosine deaminase, purine nucleoside phosphorylase were measured in the kidney cortex and medulla of the mice, along with concentration of nucleotides in kidney cortex, kidney medulla and serum. Results showed that high-dose decaffeinated coffee (HDC) led to an increase in ecto5′-nucleotidase activity in kidney cortex and an increase in adenosine concentration, as well as a decrease in plasma creatinine concentration. This suggests that HDC may improve kidney excretion function. Further studies are needed to explore the effects of other compounds, other than caffeine, present in coffee on kidney function and nucleotide metabolism.

p < 0.20). However, the only significant predictor in the multivariate Cox proportional hazard regression model was the MPA AUC [0–12], p = 0.03. Summary This study examined the importance of early mycophenolic acid (MPA) exposure in the cyclosporine- and mycophenolate mofetil (MMF)-treated kidney transplant population. Results from the study show that MPA AUC [0–12] on day 3 was predictive of efficacy (c = 0.72, p = 0.007) and adequate MPA exposure is also important with basiliximab induction therapy (c = 0.80, p = 0.01). The best cutoff point for MPA AUC [0–12] to predict efficacy was 22 mg*h/L (sensitivity 82%, specificity 64%, negative predictive value 89% and positive predictive value 30%). The results of this study suggest that early adequate exposure to MPA by day 3 is associated with low acute rejection but cannot predict toxicity. Thus, an early and adequate exposure of MPA is important for reducing the risk of rejection in kidney transplant patients.

The recent outbreak of nephrolithiasis and acute kidney injury in China, linked to ingestion of milk-based infant formula contaminated with melamine, has serious consequences for the health of children. This epidemic of environmental kidney disease highlights the morbidity associated with adulterated food products and their potential to cause long-term damage to the kidney. It serves as a reminder of the vulnerability of the kidney to environmental toxins, and that nephrologists and other health-care providers must be aware of a growing list of diverse potentially toxic compounds. Efforts should be made to investigate and prevent similar outbreaks in the future.

those who drank <1 cup/d. This difference was mainly explained by the higher eGFR among those who drank >6 cups/d at baseline (2.41 mL . min–1 . 1.73 m–2 higher eGFR). Coffee consumption was not associated with subsequent changes in eGFR. Conclusions: High coffee consumption is associated with higher eGFR at baseline but not with subsequent changes in eGFR. This article discusses the relation between coffee and tea consumption and estimated glomerular filtration rate (eGFR). Results from the Doetinchem Cohort Study found that tea consumption was not associated with eGFR, while those who drank more than 6 cups of coffee per day had a 1.33 mL. min–1 . 1.73 m–2 higher eGFR than those who drank 6 cups/day. This difference was mainly explained by the higher eGFR among those who drank more than 6 cups/day compared to those who drank less than 1 cup/day at baseline. Coffee consumption was not associated with subsequent changes in eGFR. Therefore, high coffee consumption is associated with higher eGFR at baseline, but not with subsequent changes in eGFR. While further research is needed to understand why this difference occurs, these findings suggest that drinking more than 6 cups of coffee a day may be beneficial for kidney function.

Coffee consumption is a widely popular activity in the United States, and is the primary source of caffeine intake for adults. Research suggests that regular consumption of coffee can be beneficial for cardiovascular health, as well as for protection against neurodegenerative diseases, improved asthma control, and lower risk of certain gastrointestinal diseases. However, there are potential risks associated with it due to its high caffeine content, such as anxiety, insomnia, tremulousness, palpitations, and bone loss. Although most of the health benefits are based on observational data, a daily intake of 2-3 cups appears to have neutral to beneficial effects. Ultimately, the decision to consume coffee should be weighed against the potential risks and benefits it may carry.

< 0.001). Conclusions: This study suggests that coffee consumption may increase AFI in pregnant women with isolated borderline oligohydramnios, but it had no effect on FRABF indices. This clinical study explored the effects of coffee consumption during pregnancy on amniotic fluid index (AFI) and fetal renal artery blood flow (FRABF). The study included 63 participants with isolated borderline oligohydramnios who agreed to drink one cup of instant coffee and 63 participants with the same diagnosis who did not drink the coffee. Results showed that AFI increased significantly six hours after drinking coffee, however, FRABF indices were similar before and after intake. This study suggests that coffee may increase AFI, but has no effect on FRABF indices in pregnant women with isolated borderline oligohydramnios. Although more research is needed in this area, this study provides additional insight into the effects of coffee during pregnancy.