Summary
A large cohort study analyzed 246 COVID-19 positive patients and 2460 COVID-19 negative patients with similar characteristics as control. Mean lab results of the two groups were compared during nine time intervals around PCR testing. 66 unique lab tests showed significant differences, including increased SARS-CoV-2 IgG and reduced oxygen saturation in COVID-19 positive patients after diagnosis.COVID-19 positive patients had higher fibrinogen and lower platelets at diagnosis but declining fibrinogen and increasing platelets subsequently.101 COVID-19 positive patients developed thromboses within 30 days of diagnosis, especially deep vein thromboses. However, only 5 had disseminated intravascular coagulation.Some COVID-19 positive patients developed thromboses with declining platelets, but platelets increased in most and were not associated with thrombosis.Early hyperfibrinogenemia resolved in most COVID-19 positive patients and was not always associated with thrombosis.A minority of COVID-19 positive patients developed consumptive coagulopathy-associated thromboses.Thromboprophylaxis guidelines may need refining for COVID-19.
COVID-19 patients with elevated C-reactive protein, lymphopenia, or increased lactate dehydrogenase may need intensive care. Laboratory findings are important for interpreting and managing patient care.
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ZL Zhang, YL Hou, DT Li, FZ Li - … and laboratory investigation, 2020 - Taylor & Francis
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Testing the inclusion of laboratory parameters in blood samples to improve the accuracy of COVID-19 diagnosis using rapid antigen tests (RAT) was investigated. Results showed that combining laboratory parameters with RAT results can enhance the identification of COVID-19 patients.
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RM Amer, M Samir, OA Gaber, NA El-Deeb… - Journal of Infection and …, 2021 - Elsevier
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375 SARS-CoV-2-positive pregnant women and their neonates were evaluated from various studies conducted between December 2019 and July 2020. The information extracted included study details, maternal and infant characteristics, blood assays, and vertical transmission of COVID-19.
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C Zhang, H Chu, YV Pei, J Zhang - … in Global Women's Health, 2021 - frontiersin.org
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Recovery was achieved in more than half of the lung cancer patients with COVID-19, including those who required intubation. Multiple data sources were used to identify the patients.
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J Luo, H Rizvi, IR Preeshagul, JV Egger, D Hoyos… - Annals of …, 2020 - Elsevier
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Genetic factors influence antibody responses after vaccination, as seen in previous studies on other vaccines. A new study examines the genetic variation in COVID-19 vaccine responses.
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AJ Mentzer, D O'connor, S Bibi, I Chelysheva… - Nature medicine, 2023 - nature.com
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PCT release is induced by bacterial infections, not viral infections. In our institution, PCT testing is restricted to intensive care units and requires approval from laboratory specialists in other wards.
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A Dolci, C Robbiano, E Aloisio, M Chibireva… - … and Laboratory …, 2021 - degruyter.com
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Several studies have found genetic regulators of platelet count and size. Platelet immaturity has a distinct transcriptome.
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TJ Barrett, S Bilaloglu, M Cornwell, HM Burgess… - Journal of Thrombosis …, 2021 - Elsevier
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The 4CE Consortium formed to collect electronic health record data from hospitals in four countries to study COVID-19. They evaluate if models trained in one country can be used elsewhere.
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GM Weber, C Hong, Z Xia, NP Palmer, P Avillach… - NPJ digital …, 2022 - nature.com
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A study analyzed the lab results of COVID-19 positive and negative patients. COVID-19 positive patients had changes in 66 lab tests, higher fibrinogen, lower platelets, and 101 developed blood clots.
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…, RK Pruthi, DE Houghton, JC O'Horo… - Elife, 2020 - elifesciences.org
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TWAS identifies 27 genes associated with COVID-19 hospitalization.
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GA Pathak, K Singh, TW Miller-Fleming… - Nature …, 2021 - nature.com
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