Summary
Post-acute sequelae of COVID-19 (PASC) or long COVID refers to persisting symptoms and complications following the acute phase of SARS-CoV-2 infection. Several studies have reported debilitating symptoms even after recovery from COVID-19, such as fatigue, shortness of breath, chest pain, joint pain, and cognitive impairment. The pathophysiology of PASC is still not well understood and is being actively investigated. Microclots or microthrombi in the blood have been proposed as a potential mechanism contributing to the signs and symptoms of PASC. Whole blood analysis from PASC patients has shown increased microclot formation compared to controls. Proteomic analysis of these microclots revealed the presence of inflammatory molecules trapped within the microclots. The microclots are thought to potentially obstruct blood flow and contribute to end-organ damage and inflammation. These findings suggest that the microclots could be a diagnostic biomarker for PASC and further study of their composition may provide insight into disease mechanisms and treatment targets.
The research refers the outcomes of international research in post-acute sequelae of COVID-19(PASC). It's to emphasize the pathophysiological mechanisms of PASC in PCR-negative patients recovered from COVID-19: long-persistent hyperactivated immunesystem, hyper-inflammation, hyper-coagulation,hypo-fibrinolysis, micro-thrombosis, antibodies formation, and multiorgan dysfunction.The challenges and possibilities in PASC complication diagnostics are discussed.
Published By:
L. Mukhomorova - Laboratornaya i klinicheskaya meditsina Farmatsiya
2022
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0
Mice with Alzheimer's disease and Covid receptors showed neurological changes like those in long Covid.
Published By:
G. Pasinetti - undefined
2022
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0
LongCovid or Post-Acute Sequelae of COVID-19 (PASC) is diagnosis for patients with debilitating chronic symptoms after SARS-CoV-2 infection.We used fluorescence microcopy to identify unique fibrin/amyloid micro-thrombosis and hyperactivated platelets in PASC individuals.These microclots may impede blood flow.Whole blood from 30 matched healthy and 30 PASC subjects was collected. Platelet poor plasma (PPP) prepared and viewed with fluorescence microscopy. After PPP digestion, proteomic analysis performed.Significant microclot load observed in PASC PPP compared to healthy PPP.Proteomic analysis revealed inflammatory molecules within digested microclots.Results suggest microclots in PPP may be PASC diagnostic biomarker.Characterization of inflammatory molecules and antibodies trapped within microclots might provide insight into PASC pathogenesis and novel treatment strategies. A) Microclots in healthy plasma. B) Microclots in PASC plasma.
Published By:
M. Walker - Circulation
2022
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1
Weidentified immunesignatures inplaq and infl patientsshowing inflammatoryand autoimmune activity.
Published By:
M. Woodruff - undefined
2022
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0
Cases had double controls reporting symptoms 2 years after COVID; fatigue, altered smell/taste were most common. 36% improving symptoms; 46% saw doctors;many reported work impact
Published By:
J. Logue - Open Forum Infectious Diseases
2022
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0
Post-COVID-19 neuropsychological analysis and follow-up revealed that anosmia and ageusia had largely resolved after 8-months.
Published By:
P. Pimental - Archives of Clinical Neuropsychology
2021
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0
People with long COVID have higher levels of certain immune cells called low-density granulocytes for a long time. Activated LDGs and platelet-neutrophil aggregates may relate to long COVID lung problems.
Published By:
Logan S. Dean - bioRxiv
2022
Cited By:
1
COVID-19 survivors had higher health risks for 6 months,with problems across organs like respiratory, nervous system and cardiovascular issues. They reported fatigue, pain; drug use rose.
Published By:
Z. Al‐Aly - undefined
2021
Cited By:
3
Fatigue and poor quality of life are common post-COVID-19 symptoms, with 94.9% of recovered patients experiencing at least one symptom in a study of 158 patients .
Published By:
Ayman Iqbal - Cureus
2021
Cited By:
95
Sustained viral shedding and heightened inflammatory markers during acute COVID-19 associated with post-acute sequelae 4-8 months later.
Published By:
Scott Lu - Open Forum Infectious Diseases
2022
Cited By:
0