SARS-CoV-2, the virus that causes COVID-19,has significant impacts on laboratories. SARS-CoV-2 is highly transmissible between people, especially in indoor spaces. This poses risks to laboratory staff and the community. Strict safety protocols like physical distancing, hand hygiene, cough etiquette, environmental cleaning, and adequate ventilation can help lower transmission risks but do not eliminate them. Some laboratory procedures may also increase exposure risks. Aerosol-generating procedures, including some used in research, diagnostic, and forensic laboratories, can spread droplets and aerosols containing SARS-CoV-2. Lowering risks from these procedures requires additional precautions like using biological safety cabinets. To continue operating during this pandemic, laboratories must establish COVID-19 prevention plans. These include training staff on COVID-19 risks and controls, screening staff for symptoms, enabling work from home when possible, staggering work schedules and breaks to avoid crowding, and preparing for temporary closures if cases are identified. SARS-CoV-2 may also directly impact some laboratory work. Environmental monitoring shows SARS-CoV-2 RNA can persist on surfaces for days. This contamination could interfere with sterile procedures or sensitive assays if not properly controlled. Some laboratories have also reported issues with reagent or supply shortages due to the pandemic. Maintaining core laboratory testing during COVID-19 requires monitoring supply chains and developing contingency plans to minimize disruptions. In summary, the COVID-19 pandemic significantly impacts laboratory health and safety, operations, and work processes. Comprehensive prevention and control measures are required to lower risks from SARS-CoV-2 exposure in laboratories, enable continued operation, and avoid contamination issues. Careful monitoring and planning can help laboratories adapt to changes from this health emergency and continue fulfilling their important roles.